Legionella usurps host cell lipids for vacuole expansion and bacterial growth.

Ghosh S, Bandyopadhyay S, Smith DM, Adak S, Semenkovich CF, Nagy L, Wolfgang MJ, O’Connor TJ. (2024) PLoS Pathogens. 20:e1011996.

 

Novel induction of broad-spectrum antibiotics by the human pathogen Legionella.

Shin CJ, O’Connor TJ. (2024) mSphere. e0012024.

 

Etomoxir: A Promiscuous Fatty Acid Mimetic Chemoproteomic Probe.

Choi J, Smith DM, Lee YJ, Cai D, Hossain MJ, O'Connor TJ, Deme P, Haughey NJ, Scafidi S, Riddle RC, Wolfgang M. (2024) iScience. 27:110642.

 

Peptidoglycan deacetylation controls Type IV secretion and the intracellular survival of the bacterial pathogen Legionella pneumophila.

Boamah D, Gilmore MC, Bourget S, Ghosh A, Hossain MJ, Vogel JP, Cava F, O’Connor TJ. (2023) Proc Natl Acad Sci USA. 120:e2119658120.

 

Legionella pneumophila inhibits type I interferon signaling to avoid cell-intrinsic host cell defense.

Allen C, Banks D, Shuster M, Vogel S, O’Connor TJ, Briken V. (2023) Infect Immun. 16:e0036523.

 

An efficient and cost-effective method for disrupting genes in RAW264.7 macrophages using CRISPR-Cas9. Hossain MJ, O’Connor TJ. (2023) PLoS One. 19(3):e0299513.

 

Complete genome sequence of Bacillus safensis Strain AHB2, isolated from African raw honey from Kajo Keji, South Sudan. Shin CJ, O’Connor TJ. (2022) Microbial Res Ann. 11:e0051522.

 

Complete genome sequence of an African raw honey bacterial isolate, Bacillus safensis Strain AHB11. Shin CJ, O’Connor TJ. (2022) Microbial Res Ann. 11:e0051622.

 

Combinatorial selection in environmental hosts drives the evolution of a human pathogen.

Park JM, Ghosh S, O’Connor TJ. (2020) Nat Microbiol. 5:599.

Highlighted In: Faculty of 1000 Prime, February, 2020.

 

From many hosts, one accidental pathogen: the diverse protozoan hosts of Legionella.

Boamah DK, Zhou G, Ensminger AW, O’Connor TJ (2017) Front Cell Infect Microbiol. 7:477.

 

Beyond paralogs: the multiple layers of redundancy in bacterial pathogenesis.

Ghosh S and O’Connor TJ. (2017) Front Cell Infect Microbiol. 7:467.

 

Iron triggers early egress by the intracellular bacterial pathogen Legionella pneumophila.

O’Connor TJ, Zheng H, VanRheenen SM, Ghosh S, Cianciotto NP, Isberg RR (2016) Infect Immun. 84:2185-2197.

 

iMAD: a genetic screening strategy to dissect complex interaction between a pathogen and its host. O’Connor TJ, Isberg RR (2014) Nature Protocols. 9:1916-1930.

 

​

Pre-2013

 

Analysis of Legionella infection using RNA interference in Drosophila cells.

De Jesus DA, O’Connor TJ, Isberg RR (2013) Methods Mol Biol 954:251-264.

 

Legionella: Methods and Protocols. Chapter: Analysis of Legionella infection using RNA interference in Drosophila cells.

De Jesus DA, O’Connor TJ, Isberg RR (2011) Humana Press, New York, NY.

 

Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogen.

O’Connor TJ, Boyd D, Dorer M, Isberg RR (2012) Science 338:1440-1444.

Highlighted In:

Faculty of 1000 Prime, May, 2013.

American Society for Microbiology, Small things considered (http://schaechter.asmblog.org). Putting redundancy to work by Katrina Nguyen, April, 2013.

BioTechniques. What a Pathogen Needs by Rachael Moeller Gorman, December, 2012.

 

Autophagy inhibition by irreversible deconjugation of Atg8 proteins from membranes.

Choy A, Dancourt J, Mugo B, O’Connor TJ, Isberg RR, Melia T, Roy CR (2012) Science 338:1072-1076.

 

Minimization of the Legionella pneumophila genome reveals chromosomal regions involved in host range expansion.

O’Connor TJ, Adepoju Y, Boyd D, Isberg RR (2011) Proc Natl Acad Sci 108:14733-14740.

Highlighted In: Faculty of 1000 Prime, May, 2012.

 

The E Block motif is associated with Legionella pneumophila translocated substrates.

Huang L, Boyd D, Amyot WM, Hempstead AD, Luo ZQ, O'Connor TJ, Chen C, Machner M, Montminy T, Isberg RR. (2011) Cell Microbiol 13:227-245.

 

The Legionella pneumophila replication vacuole: making a cosy niche inside host cells.

Isberg RR, O’Connor TJ, Heidtman M (2009) Nature Reviews Microbiology 7:13-24.

 

Mechanisms of Intracellular Survival and Replication of Legionella pneumophila.

O’Connor TJ, Heidtman M, Isberg RR. (2008) Legionella: Molecular Biology. Chapter 10. Caister Academic Press, Norfolk, UK.

 

Members of a Legionella pneumophila family of proteins with ExoU/phospholipase A active sites are translocated to target cells.

VanRheenen S, Luo ZQ, O’Connor TJ, Isberg RR. (2006) Infect Immun 74:3597-3606.